I don t think it’s arrived yet in psychology enough.

Why that occurs is not completely understood, but increasingly Rosetta stone
microRNAs are considered tiny molecules that have a big impact in a number of physiological processes.For his cardiovascular disease research, Elton found that a genetic trait in some people caused one specific microRNA to be bad at its job, leading to high protein levels that contribute to cardiovascular disease. This malfunctioning molecule is called microRNA-155, or miR-155.So we became interested in miR-155, and it is on chromosome 21. That's how we jumped to Down syndrome, Elton said.There is also a strong link between the heart and Down syndrome. About half of those with the syndrome are born with congenital heart defects -- problems with the heart's anatomy, not coronary arteries. But they do not experience cardiovascular disease or high blood pressure.The advent of biomedical informatics has allowed scientists to use supercomputers to explore the human genome in a search for genes and their various relationships in the context of human disease. Elton consulted a bioinformatic database and found that five microRNAs sit on chromosome 21, and he and colleagues demonstrated in previous research Rosetta Stone Chinese
that all five of them are overexpressed in the tissues, brains and hearts of Down syndrome patients.That means that whatever proteins these microRNAs work with are underexpressed, Elton said.Further database exploration suggested that these five microRNAs target 1,695 proteins, all of which could cause problems in Down syndrome because they are underexpressed. To narrow that to a more manageable number, Elton's group had to make an educated guess based on a variety of data, including which proteins that are connected to these microRNAs are made by cells in the brain and heart -- two areas most commonly affected by Down syndrome.A protein surfaced as an attractive target to study: methyl-CpG-binding protein 2, known as MeCP2. Among the reasons it’seemed important: A mutation in this protein is already known to lead to Rett syndrome, a cognitive disorder.So we thought that it was more than a coincidence that this protein plays a role in normal brain development, and if the protein doesn't function right, you're going to have cognitive impairment. Maybe this is the connection, Elton said. We still don't know if Rosetta Stone Chinese Levev 1-3
this is the most important protein related to Down syndrome. But we were able to go on and prove scientifically that MeCP2 is a target of these microRNAs on chromosome 21.The researchers used just two of the five microRNAs on chromosome 21 for the experiments in this study, miR-155 and miR-802, to match the only microRNAs available in the genetically engineered mouse model of Down syndrome.First, the researchers made copies of the relevant microRNAs.

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